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The Role of Total Organic Carbon (TOC) Validation Techniques in the Pharmaceutical Industry

Posted by Tyler Trent on Wed, May 18, 2022 @ 04:03 PM

Pharmaceutical production entails strict quality control and precise analytical testing methods. The United States Pharmacopeia (USP), European Pharmacopeia (EP) and Japanese Pharmacopeia (JP) have promoted TOC analysis as the analytical technique to verify that cleaning validation, purified water (PW) and water for intravenous injection (WFI) meet the high standards of the pharmaceutical industry.

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Tags: TOC, Cleaning Validation, Pharmaceutical Analysis, Water for Injection

What is Total Organic Carbon (TOC)?

Posted by Tyler Trent on Thu, Mar 24, 2022 @ 03:54 PM

Total Organic Carbon (TOC) is defined as the amount of carbon bound in an organic compound and is often used as a non-specific indicator of water quality or cleanliness of pharmaceutical manufacturing equipment.

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Tags: TOC

Returning to work after COVID-19

Posted by Jacob Rebholz on Wed, Apr 01, 2020 @ 12:03 PM

Hello all,

For those of you who are reading this from your office, or laboratory, please do be safe and thank you for the essential functions that you continue to serve, despite the risk to you and your family. We are all grateful for your efforts. However, if you’re like me right now, you are reading this from home. While it is certainly an adjustment (how is it possible that two toddlers can sound like a herd of elephants migrating through a bubble wrap factory!?), it is very important for those of us who can, to stay home and slow the spread of COVID-19. All the same, it is probably difficult being away from your instruments, even if this is a good time to catch up on other tasks. When all of this comes to an end, and eventually we return to work, in what kind of condition will we find our instruments?

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Tags: Purge and Trap, COVID-19

EPA Acknowledges Pesticide Risk to Bees

Posted by Betsey Seibel on Thu, Sep 13, 2018 @ 03:02 PM

Bees are in trouble. Managed bee colonies in the United States have decreased from 6 million in 1947 to 2.5 million in 2016. This is more than a simple threat to the honey supply. Bees are crucial to food supply, and in fact, one-third of what we eat comes form insect-pollinated plants. The honeybee is responsible for 80 percent of that pollination.

Understanding the impact of pesticides has become a major fight of the Environmental Protection Agency, which recently found that “A major pesticide harms honeybees when used on cotton and citrus, but not on other crops like corn, berries and tobacco.”

The EPA completed the first scientific risk assessment of the neonicotinoids, a class of pesticides debated by scientists, environmentalists and beekeepers. This is the first of four risk reports for this class of chemicals, which include neonicotinoids, clothianidin, thiamethoxam, and dinotefuran. This is also the first

 time the EPA has actually acknowledged that a major pesticide is killing bees. Anti-pesticide groups want to ban the pesticides, which works on the central nervous systems of insects. Europe banned neonics, but then lifted the ban.

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Tags: Pesticide Residue

The Dirty Dozen: List of Fruits and Vegetables that Have the Highest Pesticide Residue

Posted by Betsey Seibel on Fri, Aug 17, 2018 @ 03:15 PM

The Environmental Working Group published its annual Dirty Dozen list of the 12 fruits and vegetables with the highest pesticide residue. Topping the list the last five year were apples, but this year, strawberries were the most contaminated.

According to an EWG news release about the 2016 Shopper’s Guide to Pesticides in Produce, “Nearly all strawberry samples - 98 percent - tested by federal officials had detectable pesticide residues. Forty percent had residues of 10 or more pesticides and some had residues of 17 different pesticides. Some of the chemicals detected on strawberries are relatively benign, but others are linked to cancer, reproductive and developmental damage, hormone disruption and neurological problems.

“Strawberries were once a seasonal, limited crop, but heavy use of pesticides has increased yield and stretched the growing season. In California, where most U.S. strawberries are grown, each acre is treated with an astonishing 300 pounds of pesticides. More than 60 pounds are conventional chemicals that may leave post-harvest residues but most are fumigants - volatile poison gases that can drift into nearby schools and neighborhoods.”

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Tags: Pesticide Residue

Comparing TOC Analysis Techniques

Posted by Betsey Seibel on Wed, Mar 14, 2018 @ 01:57 PM

Teledyne Tekmar recently released a new guide that compares Total Organic Carbon analysis techniques. The guide provides important details for users and recommends the best instrument for your specific application. TOC analysis, which is used in a variety of labs, is a technique employed to determine water cleanliness and purity. It is a required test by the United States Pharmacopoeia (USP), European Pharmacopoeia (EP) and Japanese Pharmacopoeia (JP), and is frequently used to monitor wastewater, soils and drinking water safety.

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Tags: TOC

Role of Total Organic Carbon Analysis in the Cosmetics Industry

Posted by Betsey Seibel on Thu, Jan 18, 2018 @ 02:39 PM

Cosmetics.jpgTotal Organic Carbon (TOC) analysis is a process used by environmental, pharmaceutical, university and petrochemical labs to determine water cleanliness and purity. It is required analysis by international pharmacopoeia for water, wastewater and soils applications. It is also starting to find traction in other industries such as cosmetics, even though there is not a regulatory requirement to use the technique.


An article written by Ben Dingwall, a business manager at TRB Chemedica, cites the focus on quality and safety within the cosmetics industry as the reason why TOC is being used more frequently. Adoption of this purification technique is driven by a number of cosmetics companies that are “aligning the process with Current Good Manufacturing Practices (cGMP).” These best practices help companies meet established guidelines recommended by agencies that authorize and license them to manufacture and sell cosmetics.

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Tags: TOC, Cosmetics

Global Supply of Helium Dropping, Hope in New Found Reserves

Posted by Betsey Seibel on Wed, Nov 01, 2017 @ 08:07 AM

Roughly 30 percent of the world’s helium supplies comes from Qatar. Earlier this year, a blockade of Qatar by surround countries cut Qatar’s main route out of the country when Saudi Arabia and several other countries in the Middle East cut diplomatic ties with Qatar over concerns about Iran and extremists.


As a result of the blockade, experts were estimating another round of shortages and dramatic price increases for scientific instrument users. To offset the potential challenges of reduced supply coming from the region, U.S. Bureau of Land Management (BLM), which accounts for about 20% of global helium supply, ramped up production during the summer at its Cliffside facility in Texas. For the past several decades, the U.S. reserves in Texas have been the main source of helium worldwide. By 2021, commercial supplies of the gas at that location will end.


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Tags: helium

The Role of Mentoring in the Lab

Posted by Betsey Seibel on Thu, Oct 26, 2017 @ 01:47 PM

“Research shows that the presence of effective mentoring relationships in the lives of early-career scientists is a strong indicator for career success.[i]


Many people can point to individuals that have helped them along their career path and life journey. For some, mentors have not only provided them personal and professional guidance, they have also given them a big break. They credit their mentors for their current positions and continue to lean on them for ongoing support.


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Tags: application chemist

Analytical Trap Comparison for USEPA Method 8260C

Posted by Betsey Seibel on Wed, Aug 30, 2017 @ 08:33 AM

EPA Method 8260C is used to determine volatile organic compounds in a variety of solid waste matrices. It is applicable for nearly all types of samples, including air sampling trapping media, ground and surface water, aqueous sludges, caustic liquors, acid liquors, waste solvents, oily wastes, mousses, tars, soil, sediments and more. The compounds can be introduced into gas chromatography-mass spectrometry systems with purge and trap being the most common technique.


A major component of any purge and trap system is the analytical trap, which is responsible for retaining the VOCs during the purge cycle and releasing them upon heating. The VOCs are then transferred to the GC/MS for separation and detection. Teledyne Tekmar completed a study that compares four traps commonly used for purge and trap analysis using an automated VOC sample prep system and USEPA Method 8260C.


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Tags: EPA Method 8260C, Analytical Trap

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